Mucin gene expression in human embryonic and fetal intestine

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Mucin gene expression in human embryonic and fetal intestine.

BACKGROUND The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplastic and neoplastic tissues can express fetal phenotypic characteristics. AI...

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Human bronchus and intestine express the same mucin gene.

The amino acid and sugar composition of mucins from various organs is similar but not identical. This could arise by one or more of the following: organ-specific processing of a single core protein, organ-specific splicing of a single mucin mRNA, or organ-specific expression of various mucin genes. To begin to investigate the source of this variability, we examined (a) immunological cross-react...

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Overlapping gene expression in fetal mouse intestine development and human colorectal cancer.

Pathways relevant to cancer are well known to overlap with fetal development, as reflected in reactivation of embryonic genes in tumors. However, molecular evidence for this notion has gathered in piecemeal fashion, and systematic approaches have rarely been applied to gauge the extent and global characteristics of the overlap in gene expression between developing tissues and cancer. The fracti...

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The effects of herbal plants on Mucin 2 gene expression and performance in ascetic broilers

The mucus layer plays an important role as an intermediate for the protection of the gut against acidic chyme, digestive enzymes, and pathogens; in addition, it acts as a lubricant and facilitator of nutrient transportation. Phytogenic compounds seem to promote intestinal mucus production. OBJECTIVES: The current study was conducted to investigate the effects of low and high levels of energy an...

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PURPOSE It is important to understand the development of the normal retinal vascular system, because it may provide clues for understanding the mechanisms underlying the neovascularization associated with several retinopathies of infancy and adulthood. However, little is known about normal human ocular vascularization. VEGF is a key growth factor during vascular development and one of its recep...

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ژورنال

عنوان ژورنال: Gut

سال: 1998

ISSN: 0017-5749,1468-3288

DOI: 10.1136/gut.43.4.519